Desmin Mutation Responsible for Idiopathic Dilated Cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Desmin mutation responsible for idiopathic dilated cardiomyopathy.
BACKGROUND Idiopathic dilated cardiomyopathy, of which approximately 20% of cases are familial (FDCM), is a primary myocardial disorder characterized by ventricular dilatation and impaired systolic function. It is a common cause of heart failure and the need for cardiac transplantation. Although 6 chromosomal loci responsible for autosomal dominant FDCM have been mapped by linkage analysis, non...
متن کاملDilated cardiomyopathy and the desmin gene.
To the Editor: Li et al1 report a mutation screening study of actin and desmin genes in 44 probands with familial dilated cardiomyopathy (DCM) and conclude that a mutation of the desmin gene can cause DCM. We believe that the genetic data are not yet sufficient to justify this conclusion. Attempts to find genes for autosomal dominant DCM by linkage analysis have been frustrating; although 6 chr...
متن کاملPrevalence of desmin mutations in dilated cardiomyopathy.
BACKGROUND Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene. Mutations in the central 2B domain of DES cause skeletal muscle disease that typically precedes cardiac involvement. However, the prevalence of DES mutations in dilated cardiomyopathy (DCM) without skeletal muscle disease is not known. METHODS AND RESULT...
متن کامل[Familial dilated cardiomyopathy in patients transplanted for idiopathic dilated cardiomyopathy].
OBJECTIVE To evaluate the prevalence, clinical features, and pattern of inheritance of familial dilated cardiomyopathy (DCM) in heart transplant patients. PATIENTS AND METHOD Patients with idiopathic DCM who had undergone heart transplantation were invited to participate. Patients with alcohol abuse were excluded. A clinical evaluation, 12-lead ECG, echocardiogram, blood tests, and DNA extrac...
متن کاملIdiopathic Dilated Cardiomyopathy
Background Autoantibodies against the 81-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of P1-blockade in some of these patients. Methods and Results Autoantibodies against ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.100.5.461